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Abstract

Objective: The aim of this study is to determine whether there is a change in serum levels of the anti-microbial peptides Hepcidin-25 and angiogenin, in pediatric patients with Brucellosis compared to healthy controls. In addition, to evaluate their role in brucellosis and relationship with complications of brucellosis. Methods: In our study, children aged 3 to 18 years were included. There were 50 patients in the brucellosis group and 40 healthy children in the control group. Serum hepcidin-25 and angiogenin levels were studied, as well as complete blood count, alanine aminotransferase, aspartate aminotransferas, C-reactive protein, erythrocyte sedimentation rate. The relationship between these antimicrobial peptide levels and other blood parameters were evaluated. Results: There was no statistically significant difference between hepcidin-25 levels and angiogenin levels between the twogroups. No statistically significant correlation between hepcidin-25 and angiogenin levels and age or other laboratory parameters were found. Hepcidin-25 and angiogenin levels were similar between the four patients with complications of brucellosis and those without. Similarly, there was no statistically significant difference between hepcidin-25 and angiogenin levels of the seven patients who relapsed compared to those who did not. Conclusion: In our study, it was observed that hepcidin-25 and angiogenin levels, did not differ significantly between healthy children and those with brucellosis. We believe that more comprehensive prospective studies with a larger number of patients and inclusion of other antimicrobial peptides should be conducted to better understand the pathogenesis of brucellosis.

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